Sustamine® is a dipeptide consisting of two amino acids (L-alanine and L-glutamine) connected by a peptide bond. Sustamine is stable in both heat and acids, is highly soluble, and can function as a source of glutamine in the body.


Best Sustamine

#1 Real Supplements Rated Best in 2020
Genius Electrolyte Powder – Natural Hydration Booster | Endurance Supplement with Electrolytes (Potassium, Magnesium, Zinc) - Sugar Free, Vegan, Keto Friendly Energy - Orange Fizz (Drink Mix), 30 Sv
  • THE SMART SPORTS DRINK - Most of the leading sports drinks are packed with sugar. Genius Electrolyte powder contains absolutely no sugar, artificial flavoring, sweeteners, fillers, or dyes. This electrolyte supplement contains, chelated magnesium, potassium, zinc, organic citric acid , and other quality replenishing minerals.
  • CRAMP DEFENSE & MUSCLE RECOVERY - No other electrolyte tablet, packet or pill provides the same effectiveness against cramps & dehydration. With a full dose of potassium bicarbonate (comparable to potassium citrate) no other hydrator on the market helps you replenish like this. Use pre, post or intra workout for optimal recovery
  • PUSH YOUR LIMITS (The Smart Way) - When you need a low calorie, no sugar, option to boost your training, just add Genius to water. Not only are these electrolytes keto friendly they are 100% pure & simple trace minerals. This electrolyte drink doesn’t skimp out on quality. It is both made and manufactured in the USA within a GMP and FDA compliant facility. Third Party tested for potency and purity.
  • PARTY SMART - Genius Electrolytes is the smart recovery drink. The ultima replenisher , Genius Electrolytes restores and replenishes the body of its proper nutrients, hydrating you and getting you back to peak performance. Choose the Genius recovery hangover drink. Go out and thrive, plus feel your best the next morning!
#2 Real Supplements Rated Best in 2020
PEScience TruGlutamine Unflavored (Superior Glutamine Formula), 12.17 oz - 30 servings
  • 10g Per Serving | 300g Per Container
  • Featuring Patented Sustamine | Superior Glutamine Blend
  • Tasteless | Mix With Any Beverage!
#3 Real Supplements Rated Best in 2020
Metabolic Nutrition | T.A.G. (Trans Alanyl Glutamine) | 100% L-Glutamine Peptide Powder | Pre, Intra, Post Workout Supplement, Creatine | Muscle Building| 400 Grams (40 Servings) Unflavored
  • T.A.G. (Trans Alanyl Glutamine) Targeted Muscle Recovery Amino Acid supplies 100% enzymatically and fermented pharmaceutical grade dipeptide L-Alanyl L-Glutamine which delivers a massive 10g dosage per scoop. By supplementing yourself with glutamine, you can enhance your health and experience a reduced rate of infections.
  • T.A.G. (Trans Alanyl Glutamine) Targeted Muscle Recovery Amino Acid is physician formulated & designed for healthy Men or Women who are on-the-go professionals, athletes, students and competitors alike, who need and easy and quick dissolving L-Glutamine powder that tastes great and works even better to enhance their athletic training and physical recovery. Available in 3 delicious flavors, as well as, Unflavored…in 400g size…delivering 40 individual servings.
  • T.A.G. (Trans Alanyl Glutamine) di-peptide Amino Acid out performs regular L-Glutamine by bypassing regular digestion and absorbs quickly into the bloodstream for enhanced muscle growth, increase strength, prevent muscle loss and speed recovery by increasing serum amino acid levels leading to increase protein synthesis to help push your performance and physique to the next level. T.A.G. also works to support a healthier Immune Function.
  • T.A.G. is a superior form of Glutamine because it's 100% absorbed into the bloodstream and delivered right to the muscles boosting the recovery process and restricts muscle breakdown. Designed to improve muscle recovery and repair, T.A.G. stops the loss of muscle glutamine while training. T.A.G. is also helpful in boosting the immunity levels and also is responsible for vasodilation which enables enhanced blood flow to your muscles and boosts oxygen supply.
  • Suitable for Men & Women, T.A.G. have NO Calories, NO Gluten, No GMO’s, NO Lactose, NO Soy Protein, NO Added-Sugar, NO Trans Fat, NO Aspartame, NO Fillers, NO Preservatives, NO Additives, NO Amino Spiking, NO Illegal Substances and NO Gimmicks
#4 Real Supplements Rated Best in 2020
Genius Stress & Anxiety Relief Supplement w/ Ashwagandha, Nootropic Brain Booster & Memory Support w/ blueberry extract, Natural Focus, Energy & Serotonin, Calm Adrenal Fatigue & Cortisol 30 Capsules
  • FIGHT STRESS & ANXIETY – In a world full of distractions, and endless pleasure at our finger tips it is more important than ever to be mindful and conscious of our mental health. This anti stress & anxiety supplement not only promotes relaxation but also adrenal fatigue & memory support.
  • INCREASE FOCUS & ATTENTION – With constant stimuli from technology more and more people find it hard to focus and lock in for long sustained periods of time. Genius Mindfulness is a Brain booster supplement that enhances mood, focus, and healthy aging.
  • GIVE YOUR ADRENALS A BREAK – Millions of Americans suffer from poor adrenal health and don’t even know it. Symptoms include tiredness, trouble getting to sleep and waking up, craving salt and sugar, unexplained weight loss, reliance on stimulants such as caffeine, and nonspecific digestive problems. This product contains a trademarked version of Ashwagandha which helps reduce cortisol levels.
  • CALM THE MIND – The thoughts constantly occupying your mind throughout the day can be extremely powerful. It is important that everyone feeds their mind with positive and happy thoughts. This product helps boost mood, calm the mind and the body and allow you to simply be you. Your cell phone, social media, & the nightly news all take you out. It’s time to be tap in and live life the way it was intended to. Be you. Be Mindful. Be Genius.
  • THE POWER OF BLUEBERRIES x10 - Genius Mindfulness acts additionally as an antioxident supplement thanks to the nutritional benefits of AuroraBlue's proprietary blueberry complex. Unlike competitors who may only use a blueberry extract to harvest the natural power of this fruit, AuroraBlue utilizes a whole berry concentrate.
Sale#5 Real Supplements Rated Best in 2020
Glutamine Powder - Pure, Unflavored and Micronized L-Glutamine Amino Acid Supplement - 300g, 10.5oz, 60 Servings - Non GMO, Naturally Vegan, Vegetarian Friendly and Gluten Free - by Raw Barrel
  • KEEP YOUR PROTEIN SHAKE TASTY - Completely flavorless and micronized for easy dissolvable - letting you enjoy it with any delicious drink, exactly the way you like it, pre or post workout, with no bad aftertaste. Scoop included.
  • HEAL YOUR GUT - Glutamine soothes your stomach, so you feel healthier and lighter. Get more energy, mental and physical, curb sugar cravings, support your immune system, aid your digestion (IBS) and prevent leaky gut.
  • KEEP YOUR MUSCLES - maintain and boost your lean muscle growth and recovery with an increase of protein syntheses. The perfect bodybuilding dieting and weight loss supplement for men or women.
  • YOUR BODY FREE OF FILLERS AND ADDITIVES - Our glutamine is pure, clean and laboratory tested. Made in the USA, manufactured in FDA registered facility, Third Party Tested and GMP Certified. Non GMO, naturally vegan, vegetarian friendly, gluten free, soy free and caffine free.
  • YOUR BODY FREE OF FILLERS AND ADDITIVES - Our glutamine is pure, clean and laboratory tested. Made in the USA, manufactured in FDA registered facility, Third Party Tested and GMP Certified. Non GMO, naturally vegan, vegetarian friendly, gluten free, soy free and caffeine free.
#6 Real Supplements Rated Best in 2020
Metagenics Glutagenics® – Powerful Gastrointestinal Lining Support* | 60 servings
  • Supports a healthy intestinal lining, which is essential for proper digestion, immune function, and overall health*
  • Features the amino acid glutamine, which provides both a source of fuel and precursors for growth to the rapidly dividing cells of the intestinal lining*
  • Delivers a concentrated licorice extract that has been processed to remove glycyrrhizin, which has been associated with sodium and water retention*
  • Features a premium powder of decolorized inner leaf aloe to support a healthy intestinal lining*
  • This product is non-GMO, gluten-free, and vegetarian
#7 Real Supplements Rated Best in 2020
  • Ships in Certified Frustration-Free Packaging
#8 Real Supplements Rated Best in 2020
MusclePharm Essentials Glutamine Powder, Pure L-Glutamine, Unflavored, 60 Servings
  • HELPS BUILD, REPAIR, AND PROTECT MUSCLES: MusclePharm 100% Pure Glutamine Powder supplements the body with the amino acid glutamine, which helps build, repair, and protect muscles from damage.
  • PROMOTES RECOVERY AFTER INTENSE EXERCISE: Glutamine has been shown to promote recovery after intense workouts and physical exercise. Athletes and workout professionals have used L-glutamine powder as a safe supplement for years.
  • SUPPORTS GUT AND IMMUNE FUNCTION: Intense workouts and physical activity can deplete glutamine, which is critical for proper gut and immune system functioning. The introduction of 5 grams of L-glutamine improves gut and immune function.
  • BANNED-SUBSTANCE TESTED: We care about the products you put into your body. MusclePharm 100% Pure Glutamine Powder is banned-substance tested and certified by Informed-Choice.
  • 100% MONEY-BACK GUARANTEE: All MusclePharm products are backed by a 30-day full money-back guarantee.
#9 Real Supplements Rated Best in 2020
NF Sports Hydrate 2.0 – an All-Natural Daily Hydration Mix Made formulated with Electrolyte and Sustamine® to Amplify Hydration and Increase Performance. (Cucumber Mint)
  • HELPS YOU PERFORM FOR A LONGER PERIOD OF TIME | When doing a high intensity workout, this all-natural hydration mix will help you perform for a longer period of time. With a combined formula of coconut water powder and Sustamine this mix helps the body rehydrate, replenish, and recover.
  • REGULATES YOUR BODY TEMPERATURE AND LUBRICATES YOUR JOINTS | Sustamine is a revolutionary dipeptide form of L-Glutamine that supplies a combination of pure L-Glutamine (an amino acid for stimulating muscle protein synthesis) and L-Alanine (an amino acid needed for rebuilding glycogen stores). This process allows protein to be absorbed quickly, helping you regulate your body temp and perform better.
  • TRANSPORTS NUTRIENTS TO GIVE YOU ENERGY AND KEEP YOU HEALTHY | When you hydrate better your whole body reaps the rewards. By keeping up your electrolyte levels during high intensity workouts you ensure that you are transporting the nutrients your body needs everywhere, keeping your energy levels up.
  • REPLENISH VITAL WASTED ELECTROLYTES AND MINERALS | It’s no secret that when you train you expend important minerals and electrolytes. This mix is specifically designed to replenish these minerals and electrolytes throughout your entire workout keeping you going.
  • HELPS INCREASE THE ABSORPTION RATE WHEN CONSUMING WATER | Coconut Water Powder helps your body stay hydrated and absorb the electrolytes and hydration your body needs during workouts. With potassium, calcium, magnesium, phosphorous, and sodium to help balance electrolyte levels and prevent dehydration.
#10 Real Supplements Rated Best in 2020
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Best Reasons to Consider Sustamine

Sustamine® is a dipeptide consisting of two amino acids (L-alanine and L-glutamine) connected by a peptide bond. Sustamine is stable in both heat and acids, is highly soluble, and can function as a source of glutamine in the body.

Sustamine® is an ingredient that may assist with hydration and support exercise performance* Ultra-pure, clinically tested, Sustamine® is produced through a patented fermentation method to create a unique dipeptide that is more easily absorbed by the body than complex protein molecules.

Everyone has heard of glutamine, yet it’s supplement cousin, L-Alanyl-L-Glutamine, may be less familiar to many of you. Even its snappier name, Sustamine™ – is it just me, or does that sounds like a ’90s grunge band? – may not ring a bell. However, a growing body of science is causing quite a chorus of support for this unique dipeptide.

Alanylglutamine is a stable and soluble delivery form of glutamine, but are there benefits to consuming this dipeptide that go beyond what you’d expect from a glutamine and alanine supplement? I’m here to sort through the science and let you know.

What Is It?
Before diving into alanylglutamine, let’s do a brief review of its constituent parts, L-alanine and L-glutamine.

Only then will you understand why this dipeptide could help any serious athlete or physique trainer reach their goals.

Alanine is categorized as a non-essential amino acid, whereas glutamine is conditionally essential.

Yet both are vitally involved in the exchange of nitrogen between tissues and the production and/or storage of glucose.

Both affect hydration. Both are significantly affected by strenuous exercise and other forms of physiological stress.

They seem like a match made in supplement heaven.

The functions of alanine and glutamine don’t just occur in parallel; they’re incredibly synergistic:

Alanine is the most important amino acid involved in carrying nitrogen from muscle to the liver. Once there, the amino acid’s carbon skeleton can be converted to glucose as part of a process called the glucose-alanine cycle.
Glutamine is the primary transporter between cells of nitrogen derived from protein breakdown, and it stimulates glucose-like peptide-1 (GLP-1). So glutamine helps maintain blood glucose levels and supports glycogen synthesis.
Both amino acids also improve hydration in synergistic ways. Alanine appears to influence cellular hydration and volume by raising intracellular potassium concentrations, thereby drawing water into the cell. Glutamine helps maintain your body’s overall acid-base balance, because the ammonia that’s cleaved from the amino acid and delivered to the kidneys affects water transport.

In response to strenuous exercise or other forms of physiological stress, both amino acids are released from muscle in significant concentrations. If muscle concentrations of these amino acids aren’t restored, exercise performance and recovery – not to mention immune function, muscle growth and a host of other biological functions – can suffer.

Put it all together, and it’s not hard to see how any bodybuilder or athlete could benefit from taking alanine and glutamine together.

Which bring us back to L-Alanyl-L-Glutamine. Unlike a whole protein that contains peptide fractions of all sizes – with some having thousands of peptide bonds – alanylglutamine contains just one peptide bond, linking L-alanine and L-glutamine.

This single peptide fragment is called a dipeptide. (If there were a third amino acid added to this chemical, it’d be called a tripeptide. Protein fractions with more than three joined amino acids are referred to as oligopeptides.)

The benefit of consuming a dipeptide versus a mixture of its two free-form amino acids is largely a matter of stability, solubility and absorption efficiency. Specifically, whereas L-glutamine is rapidly degraded to ammonia when put into solution and is poorly soluble, alanylglutamine is incredibly soluble.

Some studies suggest that it may remain stable for more than five years! And whereas free amino acids compete for uptake via highly selective amino acid transporters, dipeptides are more efficiently absorbed via minimally selective transporters, called PEPT1 transporters.

Think of amino acid transporters as selective “bouncers” that who only let A-listers into their club, one at a time. PEPT1 transporters are “bouncers” who don’t care who enters, so long as they show up in pairs or in groups of three. Because of the easier access, blood amino acid concentrations can rise faster when di- and tri-peptides are consumed versus free amino acids.

What Does It Do?
In animal models, alanylglutamine infusion has been reported to increase nitrogen retention and weight gain; decrease muscle and whole-body protein breakdown and leucine oxidation; increase gut integrity, function and circulation; and provide support against tissue damage.

Unfortunately, few human studies have looked at alanylglutamine consumed orally rather than clinically. Drs. Roger Harris and Jay Hoffman did surmise that blood glutamine concentrations were almost 60 percent higher when subjects drank a beverage containing alanylglutamine rather than a free-form L-glutamine. Even more impressive, total plasma glutamine concentrations were almost 126% higher in response to alanylglutamine.

This and other data seems to indicate that alanine and glutamine concentrations in the blood rise significantly in response to oral alanylglutamine supplementation, and that the resulting L-glutamine is preferentially used to synthesize l-citrulline and l-arginine.

Interestingly enough, chronic ingestion of alanylglutamine appears to significantly increase muscle glutamine concentrations more than chronic L-glutamine supplementation; however, no difference in muscle glutamine stores has been reported in response to acute immediately post-exercise with either the free or dipeptide form of glutamine.

It has also been reported that chronic supplementation of either the dipeptide or equal doses of free L-alanine and L-glutamine post-exercise, resulted in no significant differences for plasma glutamine, inflammatory response, or antioxidative capacity.

Though not universal, much of the research suggests equivocal results between the use of the dipeptide versus its constituent free amino acids.

What are the performance and physique applications?
Adding alanylglutamine to a rehydration solution is significantly more effective at increasing water and electrolyte absorption than consuming either a glutamine- or glucose-containing solution.

In a study by Hoffman and associates, the researchers concluded that the increase in performance that they observed in college kids cycling to exhaustion was likely due to an increase in water and electrolyte absorption after taking a Sustamine-containing solution. Ingestion of a Sustamine-containing solution delayed the onset of fatigue under mild dehydration by almost 190%, compared to dehydrated conditions.

Hoffman’s team has also presented evidence that 1 g of alanylglutamine per 500 mL of water maintains athletic skill performance and visual reaction time better than water only Division I female athletes who became dehydrated and then drank a solution. Doubling the dose of the dipeptide per 500 mL of water decreased fatigue but did not improve performance or reaction time.

Though no human studies have looked at whether oral alanylglutamine promotes muscle hypertrophy or strength, it seems likely that such a beneficial effect would be observed under conditions of high training volumes, very low carb intake, poor hydration, or some combination of the three.

What’s the bottom line?
Though the research on oral alanylglutamine and its effects on performance and body composition remains in its infancy, the early data looks very promising.

Its role in sparing muscle protein, supporting endurance or high-intensity training performance and recovery, supporting exercise in the heat, promoting hydration and healthy immune system function, and possibly serving as a synergist during low-carb dieting all make alanylglutamine a powerful active ingredient to consider adding to your supplement toolbox.


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